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Title Year
Neutrophil-like Cell-Membrane-Coated Nanozyme Therapy for Ischemic Brain Damage and Long-Term Neurological Functional Recovery 2020
Title
Neutrophil-like Cell-Membrane-Coated Nanozyme Therapy for Ischemic Brain Damage and Long-Term Neurological Functional Recovery
Description
In this paper, the researchers suggest a noninvasive active-targeting therapy for ischemic stroke using a neutrophil-like cell-membrane-coated mesoporous Prussian blue nanozyme (MPBzyme@NCM). Despite its robust anti-inflammatory and antioxidative stress properties, nanozyme has shown unsatisfactory therapeutic effects due to its insufficient accumulation in the ischemic brain via noninvasive administration. The researchers improve its delivery to the lesion site by coating the nanozyme with the neutrophil-like membrane. They also demonstrate the long-term in vivo therapeutic efficacy for ischemic stroke after the delivery into the damaged brain. The in vivo fluorescence imaging with Visque InVivo Elite is used to confirm the accumulation of MPBzyme@NCM at the lesion site over time.
Journal
ACS Nano
Interrogation of Folic Acid-Functionalized Nanomedicines: The Regulatory Roles of Plasma Proteins Reexamined 2020
Title
Interrogation of Folic Acid-Functionalized Nanomedicines: The Regulatory Roles of Plasma Proteins Reexamined
Description
Folic acid (FA) has been widely used to promote targeted delivery of nanomedicines to tumors since the folate receptor-α (FR-α) is overexpressed in many human cancers. In this paper, the researchers find that the FA functionalization induces heavy natural IgM absorption on the liposomal surface, preventing FA from binding receptors and accelerating complement activation in vivo. In addition, FA-functionalized polymeric nanoparticles are found to be vulnerable to natural IgM absorption. The biodistribution of FA-functionalized liposome (FA-sLip) at specific time points after the tail vein is observed using in vivo fluorescence imaging with Visque InVivo Elite.
Journal
ACS Nano
Supramolecular Container-Mediated Surface Engineering Approach for Regulating the Biological Targeting Effect of Nanoparticles 2020
Title
Supramolecular Container-Mediated Surface Engineering Approach for Regulating the Biological Targeting Effect of Nanoparticles
Description
In this paper, researchers suggest a supramolecular container-based surface engineering approach to make a chemical bridge to incorporate nanoparticles and targeting ligands. The researchers use an acyclic cucurbituril (aCB) molecular container as a supramolecular container to incorporate nanoparticles and targeting ligands via a bilateral host-guest complexation, enabling better water dispersibility and enhanced biological targeting. The aCB-engineered nanoparticles show the enhanced biological targeting effect and targeted imaging performance in in vitro and in vivo experiments. The enhanced targeting and imaging performance are demonstrated by the fluorescence imaging of tumor-bearing mice with Visque InVivo Elite at the specific time point after intravenous injection of rhodamine B isothiocyanate (RITC)-labeled nanoparticle.
Journal
Nano Letters
Enhancement of Nanozyme Permeation by Endovascular Interventional Treatment to Prevent Vascular Restenosis via Macrophage Polarization Modulation 2020
Title
Enhancement of Nanozyme Permeation by Endovascular Interventional Treatment to Prevent Vascular Restenosis via Macrophage Polarization Modulation
Description
In this paper, the researchers examine nanozymes as an effective therapeutic strategy for vascular restenosis after endovascular interventional treatment. Nanozymes are excellent at scavenging ROS, the major aggravating factor for vascular restenosis, but cannot efficiently pass through the vascular endothelial cell barrier to reach the vascular intima. The researchers discover that the endothelial cells exfoliation by endovascular interventional treatment enhances nanoparticle permeation into the vascular intima and uptake by macrophages to alleviate long-term vascular restenosis in vivo. The vascular restenosis is relieved after vascular balloon injury (VBI) under the presence of Prussian blue nanozyme (PBzyme). The accumulation of PBzyme in left common carotid arteries of mice is confirmed with in vivo fluorescence imaging using Visque InVivo Elite.
Journal
Advanced Functional Materials
A molecular approach to rationally constructing specific fluorogenic substrates for the detection of acetylcholinesterase activity in live cells, mice brains and tissues 2020
Title
A molecular approach to rationally constructing specific fluorogenic substrates for the detection of acetylcholinesterase activity in live cells, mice brains and tissues
Description
In this paper, the researchers develop a specific substrate for Acetylcholinesterase (AChE) detection by combining dimethylcarbamate choline with a self-immolative scaffold. Imaging the activity of AChE which is tightly associated with neurological diseases is difficult due to the interference from butyrylcholinesterase (BChE) and carboxylesterase (CE). The representative substrate P10 can effectively eliminate the interference from CE and BChE. Its high specificity is confirmed via imaging AChE activity in vitro. Also, the AChE activity in a normal mouse brain is successfully captured via in vivo and ex vivo fluorescence imaging with Visque InVivo Elite.
Journal
Chemical Science
Molecular Design of Conjugated Small Molecule Nanoparticles for Synergistically Enhanced PTT/PDT 2020
Title
Molecular Design of Conjugated Small Molecule Nanoparticles for Synergistically Enhanced PTT/PDT
Description
In this paper, IID-ThTPA nanoparticles (IID-ThTPA NPs) are proposed as a new phototheranostic agent for simultaneous photothermal therapy (PTT) and photodynamic therapy (PDT). The researchers design a donor–acceptor–donor (D–A–D) conjugated small molecule (IID-ThTPA)-based phototheranostic agent, with isoindigo (IID) as the selective acceptor and triphenylamine (TPA) as the donor. This IID-ThTPA shows superior tumor cooperative eradicating capability in vitro and in vivo with a high PTT/PDT performance. The BioDistribution of IID-ThTPA nanoparticles in the body is identified by ex vivo fluorescence imaging of the extracted tissues with Visque InVivo Elite at specific time points after the intravenous injection.
Journal
Nano-Micro Letters
In Vivo Imaging of Senescent Vascular Cells in Atherosclerotic Mice Using a β-Galactosidase-Activatable Nanoprobe 2020
Title
In Vivo Imaging of Senescent Vascular Cells in Atherosclerotic Mice Using a β-Galactosidase-Activatable Nanopro
Description
Detection of senescence-associated β-galactosidase (SA-β-Gal) is suggested as the early diagnosis and therapy of atherosclerosis and other aging-associated diseases. The researchers develop a β-galactosidase-activatable nanoprobe BOD-L-βGal-NPs to detect SA-β-Gal which is overexpressed in senescent cells. Nanoprobe BOD-L-βGal-NPs showed good accumulation in arteries, thus successfully visualizing senescent cells and vasculature in atherosclerotic mice by in vivo fluorescence imaging after tail vein injection. The difference between the control group and the aging group is identified by in vivo fluorescence imaging with Visque InVivo Smart after tail vein injection of BOD-L-βGal-NPs into mice. And the accumulation of BOD-L-βGal-NPs in arteries is confirmed by ex vivo fluorescence imaging with Visque InVivo Smart.
Journal
Analytical Chemistry
Discovery of a Monoiodo Aza-BODIPY Near-Infrared Photosensitizer: in vitro and in vivo Evaluation for Photodynamic Therapy 2020
Title
Discovery of a Monoiodo Aza-BODIPY Near-Infrared Photosensitizer: in vitro and in vivo Evaluation for Photodynamic Therapy
Description
Monoiodo Aza-BODIPY is developed as a new Near-Infrared Photosensitizer (PS) for Photodynamic therapy (PDT), which is a rising platform of the cancer treatment method, and its antitumor efficacy is demonstrated both in vivo and in vitro. BODIPYs possess many advantages of ideal PS characteristics and aza-BODIPYs among them have large absorption coefficient and NIR absorption to fit the therapeutic window (650 - 900nm). The researchers make many substitution variations on aza-BODIPY and find that monoiodo derivatives of aza-BODIPY have various advantages of an ideal PS with excellent photostability, chemical stability, and photocytotoxicity. The superior antitumor efficacy of Monoiodo Aza-BODIPY is demonstrated both in vitro and in vivo. The biodistribution of Monoiodo Aza-BODIPY at specific time points after the tail vein injection is explored using in vivo and ex vivo fluorescence imaging of mice with Visque InVivo Smart.
Journal
Journal of Medicinal Chemistry
2020 Sep 10;63(17):9950-9964
Detecting Cysteine in Bioimaging with a Near‐Infrared Probe Based on a Novel Fluorescence Quenching Mechanism 2020
Title
Detecting Cysteine in Bioimaging with a Near‐Infrared Probe Based on a Novel Fluorescence Quenching Mechanism
Description
The highly selective and sensitive NIR turn-on fluorescent probe (BDP-NIR) was developed to detect cysteine (Cys) in biological systems. BDP-NIR was based on BODIPY with a large Stokes shift (105 nm) when detecting Cys. BDP-NIR had a high linear dynamic range from 0 μM to 500 μM, which was promising for detecting of Cys quantificationally. The researchers took fluorescence imaging of mice with Visque InVivo Elite to evaluate the capability of sensing endogenous Cys in vivo.
Journal
ChemBioChem
Heme Oxygenase 1-Targeted Hybrid Nanoparticle for Chemo- and Immuno-Combination Therapy in Acute Myelogenous Leukemia 2020
Title
Heme Oxygenase 1-Targeted Hybrid Nanoparticle for Chemo- and Immuno-Combination Therapy in Acute Myelogenous Leukemia
Description
The new hybrid nanoparticle is developed as a novel therapeutic in acute myelogenous leukemia (AML) and its potential was assessed with a human AML-bearing orthotopic mouse model. The lipid-polymer hybrid nanoparticle (hNP) is loaded with tin mesoporphyrin (SnMP), an inhibitor of Heme Oxygenase 1 (HO1) which is an antioxidative and cytoprotective enzyme inducing chemo-resistant AML, and an engineered antibody for leukemic cell-targeted delivery. HO1-inhibiting T-hNP (T-hNP/SnMP) enhances chemo-sensitivity in human leukemia cells. The T-hNP/SnMP enhances the chemo-therapeutic effect of daunorubicin and boosts immune response by reprogramming bone marrow myeloid cells. In the ex vivo study, the researchers identify the organ distribution of T-hNP/SnMP at specific time points after the intravenous injection and confirm the presence of T-hNP/SnMP in the bone marrow by fluorescence imaging of mice with Visque InVivo Smart.
Journal
Advanced Science
2020 Jul; 7(13): 2000487
Penta-fluorophenol: A Smiles rearrangement-inspired cysteine-selective fluorescent probe for imaging of human glioblastoma 2020
Title
Penta-fluorophenol: A Smiles rearrangement-inspired cysteine-selective fluorescent probe for imaging of human glioblastoma
Description
The electron-deficient penta-fluorophenol (NPO-B) was developed as a sensing fluorescence probe to measure the cysteine (Cys) level, which is a biomarker of glioblastomoa (GBM). The probe provided a significant fluorescence response with high selectivity, high sensitivity, a fast response time. The researcher identified that this probe can be used for a relatively simple diagnosis and the tracking of GBM at clinical sites by ex vivo fluorescence imaging in both mouse models and human tissue samples with Visque InVivo Elite.
Journal
Chemical Science
2020 May 11; 5658-5668
Selenium and dopamine-crosslinked hyaluronic acid hydrogel for chemophotothermal cancer therapy 2020
Title
Selenium and dopamine-crosslinked hyaluronic acid hydrogel for chemophotothermal cancer therapy
Description
Sodium selenite (Se)-directed crosslinked hydrogels based on hyaluronic acid (HA)-dopamine (HD), including indocyanine green (ICG), were developed for local cancer therapy. This HD/Se/ICG gel showed easy injectability, slow biodegradability and sufficient photothermal efficiencies with NIR laser irradiation, providing efficient tumor growth inhibition capability without severe systemic toxicities. The biodegradability of the gel in the body was tested by in vivo fluorescence imaging of mice with Visque InVivo Smart at specific time points after the intratumoral injection.
Journal
Journal of Controlled Release
2020 Apr 15;S0168-3659(20)30237-6.
Surface-Initiated Atom Transfer Polymerized Anionic Corona on Gold Nanoparticles for Anti-Cancer Therapy 2020
Title
Surface-Initiated Atom Transfer Polymerized Anionic Corona on Gold Nanoparticles for Anti-Cancer Therapy
Description
Gold nanoparticles (AuNPs) layered with siRNA were developed for anti-cancer therapy. The in vitro anti-cancer effect confirmed that AuNP showed higher degrees of apoptosis as well as suppression of the oncogene expression in a siRNA dose-dependent manner. The in vivo study revealed that mice treated with c-Myc siRNA-incorporated AuNPs showed dramatically decreased tumor size. The researcher observed the biodistribution of c-Myc siRNA-incorporated AuNPs in the body of mice by fluorescence in vivo imaging with Visque InVivo Smart.
Journal
Biomacromolecules
2020 Mar; 12(3): 261.
Multifunctional Dendrimer-Entrapped Gold Nanoparticles for Labeling and Tracking T Cells Via Dual-Modal Computed Tomography and Fluorescence Imaging 2020
Title
Multifunctional Dendrimer-Entrapped Gold Nanoparticles for Labeling and Tracking T Cells Via Dual-Modal Computed Tomography and Fluorescence Imaging
Description
Poly(amidoamine) (PAMAM) dendrimer-entrapped gold nanoparticles (Au DENPs) conjugated with Fluo-4 was developed as an efficient nanoprobe for monitoring and tracking T cells. The researchers identified T cell labeling efficiency of this nanoprobe by taking fluorescence images of mice in vivo with Visque InVivo Smart after subcutaneous injection of T cells.
Journal
Biomacromolecules
2020 Apr 13;21(4):1587-1595.
Biodegradable Mesoporous Silica Achieved via Carbon Nanodots-Incorporated Framework Swelling for Debris-Mediated Photothermal Synergistic Immunotherapy 2019
Title
Biodegradable Mesoporous Silica Achieved via Carbon Nanodots-Incorporated Framework Swelling for Debris-Mediated Photothermal Synergistic Immunotherapy
Description
The uniformly incorporating polymer-coated carbon nanodots (CDs) into ordered framework of mesoporous silica nanoparticles (CD@MSNs) was developed both for the photothermal therapy (PTT) and immunotherapy of cancer. The obtained CD@MSN showed enhanced photothermal effect and elevated targeting accumulation in vitro and in vivo. And CD@MSN-mediated PTT also showed immune-mediated inhibition of tumor metastasis by natural killer cells and macrophages. They observed biodistribution of CD@MSN by fluorescence imaging of isolated organs with Visque InVivo Smart at specific time points after injection into the body of mice.
Journal
Nano Letters
2019 Dec 11;19(12):8409-8417.
Osteogenesis and angiogenesis are simultaneously enhanced in BMP2-/VEGF-transfected adipose stem cells through activation of the YAP/TAZ signaling pathway. 2019
Title
Osteogenesis and angiogenesis are simultaneously enhanced in BMP2-/VEGF-transfected adipose stem cells through activation of the YAP/TAZ signaling pathway.
Description
The osteogenic and angiogenic effect of BMP2-/VEGF-transfected adipose stem cells are simultaneously enhanced in critical-size calvarial defects and long-bone segmental defects in immunosuppressed rats.
They identified with Visque InVivo Elite that the implanted stem cells did not migrate out of the implantation site by the 56th day.
They suggest the possibility of using gene–cell therapy that can induce rapid angiogenesis and osteogenesis in inhospitable avascular environments.
Journal
Biomaterials Science.
2019 Nov 1;7(11):4588-4602.
Targeted delivery of CRISPR interference system against Fabp4 to white adipocytes ameliorates obesity, inflammation, hepatic steatosis, and insulin resistance 2019
Title
Targeted delivery of CRISPR interference system against Fabp4 to white adipocytes ameliorates obesity, inflammation, hepatic steatosis, and insulin resistance
Description
Targeted delivery of CRISPR interference system against Fabp4 to white adipocytes were imaged and quantified with Visque InVivo Smart and its SW, Clevue in ex vivo in this paper. They suggest that targeted delivery of the CRISPRi system against Fabp4 to white adipocytes provides a simple and safe approach to regress and treat obesity and obesity-induced metabolic syndromes.
Journal
Genome Research
2019 Sep;29(9):1442-1452.
Conjugation of prostate cancer-specific aptamers to polyethylene glycol-grafted polyethylenimine for enhanced gene delivery to prostate cancer cells 2019
Title
Conjugation of prostate cancer-specific aptamers to polyethylene glycol-grafted polyethylenimine for enhanced gene delivery to prostate cancer cells
Description
The BioDistribution of gene delivery carrier were imaged and quantified with Visque InVivo Smart and its SW, Clevue in ex vivo in this paper. They suggest that PEI-PEG-Wy5a may be useful for prostate cancer-specific gene delivery.
Journal
Journal of Industrial and Engineering Chemistry
2019 May 25;73:182-191.
A nanoscale photothermal agent based on a metal-organic coordination polymer as a drug-loading framework for effective combination therapy 2019
Title
A nanoscale photothermal agent based on a metal-organic coordination polymer as a drug-loading framework for effective combination therapy
Description
The BioDistribution of photothermal agent were imaged and quantified with Visque InVivo Elite and its SW, Clevue in this paper.
Journal
Acta Biomaterialia
2019 Aug;94:435-446.
Exendin-4 protects hindlimb ischemic injury by inducing angiogenesis 2015
Title
Exendin-4 protects hindlimb ischemic injury by inducing angiogenesis
Description
The angiogenic effect of exendin-4 using a mouse hindlimb ischemia model was analyzed with real time fluorescent imaging ability and feature map analysis abilities of Clevue, the SW of Vieworks.
Journal
Biochemical and Biophysical Research Communications.
2015 Oct2;465(4):758-63.
Age-related changes in pial arterial structure and blood flow in mice 2015
Title
Age-related changes in pial arterial structure and blood flow in mice
Description
Age-related changes in cerebral blood flow and vasculature of mice were investigated with real time fluorescent imaging ability and feature map analysis abilities of CleVue, the SW of Vieworks.
Journal
Neurobiology of Aging.
2015 Jan;37:161-170
Use of indocyanine green for optical analysis of cortical infarcts in photothrombotic ischemic brains 2015
Title
Use of indocyanine green for optical analysis of cortical infarcts in photothrombotic ischemic brains
Description
The photothrombotic ischemic injury of brain using mice were analyzed and diagnosed with real time imaging ability and FluAngio and DyAngio algorithm which was developed by collaborated research of Kyung Hee University and Vieworks.
CleVue enables equivalent analysis as described in this paper.
Journal
Biochemical and Biophysical Research Communications.
2015 Oct2;465(4):758-63.
Optical measurement of mouse strain differences in cerebral blood flow using indocyanine green 2015
Title
Optical measurement of mouse strain differences in cerebral blood flow using indocyanine green
Description
The difference of cerebral blood flow between two mouse strain was analyzed and compared with feature map ability which is developed by collaborated research of Kyung Hee University and Vieworks. CleVue enables equivalent analysis as described in this paper.
Journal
Journal of Cerebral Blood Flow & Metabolism.
2015 Jun;35(6):912-6
Noninvasive Optical Measurement of Cerebral Blood Flow in Mice Using Molecular Dynamics Analysis of Indocyanine Green 2012
Title
Noninvasive Optical Measurement of Cerebral Blood Flow in Mice Using Molecular Dynamics Analysis of Indocyanine Green
Description
The cerebral blood flow of mice was investigated by real time imaging ability with ICG and fluorescence dynamics analysis ability.
CleVue enables equivalent analysis as described in this paper.
Journal
PLOS ONE.
2012;7(10):e48383.
Dynamic fluorescence imaging for multiparametric measurement of tumor vasculature 2011
Title
Dynamic fluorescence imaging for multiparametric measurement of tumor vasculature
Description
The vasculature of tumor were imaged and analyzed by realtime fluorescence imaging with ICG and analysis algorithms.
CleVue enables equivalent analysis as described in this paper.
Journal
Journal of Biomedical Optics
2011 Apr;16(4):046008.
Efficient differentiation of human pluripotent stem cells into functional CD34 progenitor cells by combined modulation of the MEK/ERK and BMP4 signaling pathways 2010
Title
Efficient differentiation of human pluripotent stem cells into functional CD34 progenitor cells by combined modulation of the MEK/ERK and BMP4 signaling pathways
Description
The vasculogenic effects of stem cell therapy on ischemic tissue of mice were investigated by analyzing the blood flow of ischemic tissue.
Journal
BLOOD.
2010 Dec16;116(25):5762-72
Unsorted human adipose tissue-derived stem cells promote angiogenesis and myogenesis in murine ischemic hindlimb model 2010
Title
Unsorted human adipose tissue-derived stem cells promote angiogenesis and myogenesis in murine ischemic hindlimb model
Description
The promotion effect of angiogenesis and myogenesis in mouse ischemic hindlimb model after treating stem cells is identified by analyzing fluorescence image of tissue.
Journal
Microvascular Research.
2010 Dec;80(3):310-6.
Quantitative Analysis of Peripheral Tissue Perfusion Using Spatiotemporal Molecular Dynamics 2009
Title
Quantitative Analysis of Peripheral Tissue Perfusion Using Spatiotemporal Molecular Dynamics
Description
The relation between perfusion rate and necrosis was investigated with realtime fluorescence imaging and analysis in mouse ischemic hindlimb model.
Journal
PLOS One. 2009;4(1):e4275.
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